STAT5B Polyclonal Antibody
- SKU:
- CAB21613
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
- Applications:
- IF
Description
| Product Name: | STAT5B Polyclonal Antibody |
| Product Code: | CAB21613 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IP 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Mouse liver, Mouse heart, Mouse thymus, Rat liver |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 586-787 of human STAT5B (NP_036580.2). |
| Sequence: | KPHWN DGAIL GFVNK QQAHD LLINK PDGTF LLRFS DSEIG GITIA WKFDS QERMF WNLMP FTTRD FSIRS LADRL GDLNY LIYVF PDRPK DEVYS KYYTP VPCES ATAKA VDGYV KPQIK QVVPE FVNAS ADAGG GSATY MDQAP SPAVC PQAHY NMYPQ NPDSV LDTDG DFDLE DTMDV ARRVE ELLGR PMDSQ WIPHA QS |
| Synonyms: | STAT5, GHISID2 |
| Calculated MW: | 90kDa |
| Observed MW: | 92kDa |
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