UniProt Protein Function: | ST8SIA3: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. Belongs to the glycosyltransferase 29 family.Protein type: Membrane protein, integral; Transferase; EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio seriesChromosomal Location of Human Ortholog: 18q21.31Cellular Component: Golgi membrane; integral to Golgi membraneMolecular Function: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; sialic acid bindingBiological Process: glycosphingolipid biosynthetic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; glycoprotein metabolic process; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; N-glycan processing; post-translational protein modification; oligosaccharide metabolic process; ganglioside biosynthetic process |
UniProt Protein Details: | |
NCBI Summary: | ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008] |
UniProt Code: | O43173 |
NCBI GenInfo Identifier: | 116242790 |
NCBI Gene ID: | 51046 |
NCBI Accession: | O43173.3 |
UniProt Secondary Accession: | O43173,Q6B085, Q9NS41, A8K0F2 |
UniProt Related Accession: | O43173 |
Molecular Weight: | 43,970 Da |
NCBI Full Name: | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase |
NCBI Synonym Full Names: | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 |
NCBI Official Symbol: | ST8SIA3 |
NCBI Official Synonym Symbols: | SIAT8C; ST8SiaIII |
NCBI Protein Information: | sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; SIAT8-C; sialytransferase St8Sia III; sialyltransferase St8Sia III; alpha-2,8-sialyltransferase 8C; alpha-2,8-sialyltransferase III; sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase) |
UniProt Protein Name: | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase |
UniProt Synonym Protein Names: | Alpha-2,8-sialyltransferase 8C; Alpha-2,8-sialyltransferase III; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Sialyltransferase 8C; SIAT8-C; Sialyltransferase St8Sia III |
Protein Family: | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase |
UniProt Gene Name: | ST8SIA3 |
UniProt Entry Name: | SIA8C_HUMAN |