| UniProt Protein Function: | DENND2B: a guanine nucleotide exchange factor (GEF) that may activate RAB9A and RAB9B. May be involved in cytoskeletal organization and tumorogenicity. Widely expressed with the exception of peripheral blood lymphocytes and lymphoid cell lines. 3 isoforms of the human protein are produced by alternative promoter. Isoform 1 interacts with the SH3 domain of ABL1, is expressed in several epithelial, fibroblast, and tumorigenic cell lines, and seems to be involved in the activation of ERK2. Isoform 3, expressed in primary cells that may be weakly tumorigenic, but not in tumorigenic cell lines, may block ERK2 activation stimulated by ABL1, and may alter cell morphology and cell growth. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, Rab Chromosomal Location of Human Ortholog: 11p15 Molecular Function:Rab guanyl-nucleotide exchange factor activity |
| NCBI Summary: | This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78524 |
| NCBI GenInfo Identifier: | 317373507 |
| NCBI Gene ID: | 6764 |
| NCBI Accession: | P78524.3 |
| UniProt Secondary Accession: | P78524,P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6 B2R6X7, B3KXQ6, |
| UniProt Related Accession: | P78524 |
| Molecular Weight: | 70,245 Da |
| NCBI Full Name: | Suppression of tumorigenicity 5 protein |
| NCBI Synonym Full Names: | suppression of tumorigenicity 5 |
| NCBI Official Symbol: | ST5 |
| NCBI Official Synonym Symbols: | HTS1; p126; DENND2B |
| NCBI Protein Information: | suppression of tumorigenicity 5 protein; heLa tumor suppression 1; DENN/MADD domain containing 2B |
| UniProt Protein Name: | Suppression of tumorigenicity 5 protein |
| UniProt Synonym Protein Names: | DENN domain-containing protein 2B; HeLa tumor suppression 1 |
| Protein Family: | Suppression of tumorigenicity 5 protein |
| UniProt Gene Name: | ST5 |
| UniProt Entry Name: | ST5_HUMAN |
