SSX1 Antibody (PACO17152)
- SKU:
- PACO17152
Description
| Antibody Name: | SSX1 Antibody (PACO17152) |
| Antibody SKU: | PACO17152 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human SSX1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: PACO17152(SSX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. |
| Synonyms: | synovial sarcoma, X breakpoint 1 |
| UniProt Protein Function: | SSX1: Could act as a modulator of transcription. A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SSX family.Protein type: Oncoprotein; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xp11.23Molecular Function: protein binding; transcription corepressor activityDisease: Sarcoma, Synovial |
| UniProt Protein Details: | |
| NCBI Summary: | The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q16384 |
| NCBI GenInfo Identifier: | 3915027 |
| NCBI Gene ID: | 6756 |
| NCBI Accession: | Q16384.2 |
| UniProt Secondary Accession: | Q16384,Q08AJ2, Q5JQ64, A3KN76 |
| UniProt Related Accession: | Q16384 |
| Molecular Weight: | 21,931 Da |
| NCBI Full Name: | Protein SSX1 |
| NCBI Synonym Full Names: | SSX family member 1 |
| NCBI Official Symbol: | SSX1 |
| NCBI Official Synonym Symbols: | SSRC; CT5.1 |
| NCBI Protein Information: | protein SSX1 |
| UniProt Protein Name: | Protein SSX1 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 5.1; CT5.1; Synovial sarcoma, X breakpoint 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | SSX1 |
| UniProt Entry Name: | SSX1_HUMAN |
| Antibodies |
| SSX1 Antibody (PACO01898) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Host Species: |
Rabbit |
Isotype: |
IgG |
Applications: |
ELISA |
Applications: |
WB |
Antibody Type: |
Polyclonal Antibody |
Conjugation: |
Unconjugated |
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