Name: SSH3 Antibody (PACO23466)
SKU: PACO23466
Availability: OutOfStock

Antibody Name:	SSH3 Antibody (PACO23466)
Antibody SKU:	PACO23466
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human SSH3.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from HuvEc cells, using SSH3 antibody.
	Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SSH3 antibody.

Background:	Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly By similarity.
Synonyms:	Protein phosphatase Slingshot homolog 3; SSH-3L; hSSH-3L;

UniProt Protein Function:	SSH3: a protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Does not bind to, or colocalize with, filamentous actin. Five alternatively spliced isoforms have been described.Protein type: Cytoskeletal; EC 3.1.3.16; Protein phosphatase, dual-specificity; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 11q13.2Cellular Component: cytoplasmMolecular Function: actin bindingBiological Process: regulation of actin polymerization and/or depolymerization; regulation of axonogenesis
UniProt Protein Details:
NCBI Summary:	The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
UniProt Code:	Q8TE77
NCBI GenInfo Identifier:	82582268
NCBI Gene ID:	54961
NCBI Accession:	Q8TE77.2
UniProt Secondary Accession:	Q8TE77,Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7
UniProt Related Accession:	Q8TE77
Molecular Weight:	16,357 Da
NCBI Full Name:	Protein phosphatase Slingshot homolog 3
NCBI Synonym Full Names:	slingshot protein phosphatase 3
NCBI Official Symbol:	SSH3
NCBI Official Synonym Symbols:	SSH3L
NCBI Protein Information:	protein phosphatase Slingshot homolog 3
UniProt Protein Name:	Protein phosphatase Slingshot homolog 3
UniProt Synonym Protein Names:	SSH-like protein 3; SSH-3L; hSSH-3L
Protein Family:	Protein phosphatase Slingshot
UniProt Gene Name:	SSH3
UniProt Entry Name:	SSH3_HUMAN