| UniProt Protein Function: | SSH3: a protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Does not bind to, or colocalize with, filamentous actin. Five alternatively spliced isoforms have been described.Protein type: Cytoskeletal; EC 3.1.3.16; Protein phosphatase, dual-specificity; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 11q13.2Cellular Component: cytoplasmMolecular Function: actin bindingBiological Process: regulation of actin polymerization and/or depolymerization; regulation of axonogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8TE77 |
| NCBI GenInfo Identifier: | 82582268 |
| NCBI Gene ID: | 54961 |
| NCBI Accession: | Q8TE77.2 |
| UniProt Secondary Accession: | Q8TE77,Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7 |
| UniProt Related Accession: | Q8TE77 |
| Molecular Weight: | 16,357 Da |
| NCBI Full Name: | Protein phosphatase Slingshot homolog 3 |
| NCBI Synonym Full Names: | slingshot protein phosphatase 3 |
| NCBI Official Symbol: | SSH3 |
| NCBI Official Synonym Symbols: | SSH3L |
| NCBI Protein Information: | protein phosphatase Slingshot homolog 3 |
| UniProt Protein Name: | Protein phosphatase Slingshot homolog 3 |
| UniProt Synonym Protein Names: | SSH-like protein 3; SSH-3L; hSSH-3L |
| Protein Family: | Protein phosphatase Slingshot |
| UniProt Gene Name: | SSH3 |
| UniProt Entry Name: | SSH3_HUMAN |
