| UniProt Protein Function: | SRY: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Defects in SRY are the cause of 46,XY sex reversal type 1 (SRXY1). A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal. A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, streak gonads, variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female. Defects in SRY are the cause of 46,XX sex reversal type 1 (SRXX1). A condition in which male gonads develop in a genetic female (female to male sex reversal). Belongs to the SRY family.Protein type: DNA-binding; Nuclear receptor co-regulatorCellular Component: cytoplasm; nucleusMolecular Function: calmodulin binding; DNA bending activity; DNA binding; protein binding; protein heterodimerization activity; transcription factor activityBiological Process: cell differentiation; male gonad development; male sex determination; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; sex determination; sex differentiation; transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q05738 |
| NCBI GenInfo Identifier: | 6755761 |
| NCBI Gene ID: | 21674 |
| NCBI Accession: | NP_035694.1 |
| UniProt Secondary Accession: | Q05738 |
| UniProt Related Accession: | Q05738 |
| Molecular Weight: | 21.2 kDa |
| NCBI Full Name: | sex-determining region Y protein |
| NCBI Synonym Full Names: | sex determining region of Chr Y |
| NCBI Official Symbol: | Sry |
| NCBI Official Synonym Symbols: | Tdf; Tdy |
| NCBI Protein Information: | sex-determining region Y protein |
| UniProt Protein Name: | Sex-determining region Y protein |
| UniProt Synonym Protein Names: | Testis-determining factor |
| Protein Family: | Sex-determining region Y protein |
| UniProt Gene Name: | Sry |
| UniProt Entry Name: | SRY_MOUSE |
