SRRM4 Antibody (PACO58805)
- SKU:
- PACO58805
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SRRM4 Antibody (PACO58805) |
| Antibody SKU: | PACO58805 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat kidney tissue, Mouse lung tissue. All lanes: SRRM4 antibody at 4.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69 kDa. Observed band size: 69 kDa. |
 | IHC image of PACO58805 diluted at 1:500 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). |
| Synonyms: | Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100), SRRM4, KIAA1853 |
| UniProt Protein Function: | Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (). |
| UniProt Protein Details: | |
| NCBI Summary: | SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | A7MD48 |
| NCBI GenInfo Identifier: | 50083281 |
| NCBI Gene ID: | 84530 |
| NCBI Accession: | NP_919262.2 |
| UniProt Secondary Accession: | A7MD48,Q7Z5F0, Q96JH4, A8K5P6, B2RZH7 |
| UniProt Related Accession: | A7MD48 |
| Molecular Weight: | |
| NCBI Full Name: | serine/arginine repetitive matrix protein 4 |
| NCBI Synonym Full Names: | serine/arginine repetitive matrix 4 |
| NCBI Official Symbol: | SRRM4 |
| NCBI Official Synonym Symbols: | nSR100; KIAA1853; MU-MB-2.76 |
| NCBI Protein Information: | serine/arginine repetitive matrix protein 4 |
| UniProt Protein Name: | Serine/arginine repetitive matrix protein 4 |
| UniProt Synonym Protein Names: | Medulloblastoma antigen MU-MB-2.76; Neural-specific serine/arginine repetitive splicing factor of 100 kDa; Neural-specific SR-related protein of 100 kDa; nSR100 |
| Protein Family: | Serine/arginine repetitive matrix protein |
| UniProt Gene Name: | SRRM4 |
| UniProt Entry Name: |
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