SRP68 Antibody (PACO20468)
- SKU:
- PACO20468
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SRP68 Antibody (PACO20468) |
| Antibody SKU: | PACO20468 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human SRP68 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20468(SRP68 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. |
| Synonyms: | signal recognition particle 68kDa |
| UniProt Protein Function: | SRP68: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Belongs to the SRP68 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Endoplasmic reticulum; Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 17q25.1Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; nucleolus; signal recognition particle, endoplasmic reticulum targeting; ribosome; cytosolMolecular Function: signal recognition particle binding; signal sequence binding; endoplasmic reticulum signal peptide binding; 7S RNA bindingBiological Process: response to drug; protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; gene expression |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012] |
| UniProt Code: | Q9UHB9 |
| NCBI GenInfo Identifier: | 37154869 |
| NCBI Gene ID: | 6730 |
| NCBI Accession: | Q9UHB9.2 |
| UniProt Secondary Accession: | Q9UHB9 |
| UniProt Related Accession: | Q9UHB9 |
| Molecular Weight: | 71kDa |
| NCBI Full Name: | Signal recognition particle subunit SRP68 |
| NCBI Synonym Full Names: | signal recognition particle 68 |
| NCBI Official Symbol: | SRP68 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | signal recognition particle subunit SRP68 |
| UniProt Protein Name: | Signal recognition particle subunit SRP68 |
| UniProt Synonym Protein Names: | Signal recognition particle 68 kDa protein |
| Protein Family: | Signal recognition particle |
| UniProt Gene Name: | SRP68 |
| UniProt Entry Name: | SRP68_HUMAN |
| Antibodies |
| SRP68 Antibody (PACO12463) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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