SRGAP3 Antibody (PACO57992)
- SKU:
- PACO57992
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SRGAP3 Antibody (PACO57992) |
| Antibody SKU: | PACO57992 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human SLIT-ROBO Rho GTPase-activating protein 3 protein (709-955AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO57992 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. |
| Synonyms: | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP), SRGAP3, ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 |
| UniProt Protein Function: | ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; Rac GTPase binding Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration |
| UniProt Code: | O43295 |
| NCBI GenInfo Identifier: | 48429207 |
| NCBI Gene ID: | 9901 |
| NCBI Accession: | O43295.3 |
| UniProt Secondary Accession: | O43295,Q8IX13, Q8IZV8, |
| UniProt Related Accession: | O43295 |
| Molecular Weight: | 1099 |
| NCBI Full Name: | SLIT-ROBO Rho GTPase-activating protein 3 |
| NCBI Synonym Full Names: | SLIT-ROBO Rho GTPase activating protein 3 |
| NCBI Official Symbol: | SRGAP3 |
| NCBI Official Synonym Symbols: | WRP; MEGAP; SRGAP2; ARHGAP14 |
| NCBI Protein Information: | SLIT-ROBO Rho GTPase-activating protein 3; mental disorder-associated GAP; rho GTPase-activating protein 14; SLIT-ROBO Rho GTPase activating protein 2; WAVE-associated Rac GTPase activating protein |
| UniProt Protein Name: | SLIT-ROBO Rho GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | Mental disorder-associated GAP; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP |
| Protein Family: | SLIT-ROBO Rho GTPase-activating protein |
| UniProt Gene Name: | SRGAP3 |
| UniProt Entry Name: | SRGP3_HUMAN |
| Antibodies |
| SRGAP3 Antibody (PACO12458) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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