SRGAP3 Antibody (PACO17144)
- SKU:
- PACO17144
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SRGAP3 Antibody (PACO17144) |
| Antibody SKU: | PACO17144 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human SRGAP3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17144(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO17144(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | SRGAP3 is a 1099 amino acid, protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events. |
| Synonyms: | SLIT-ROBO Rho GTPase activating protein 3 |
| UniProt Protein Function: | ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; Rac GTPase binding Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration |
| UniProt Code: | O43295 |
| NCBI GenInfo Identifier: | 48429207 |
| NCBI Gene ID: | 9901 |
| NCBI Accession: | O43295.3 |
| UniProt Secondary Accession: | O43295,Q8IX13, Q8IZV8, |
| UniProt Related Accession: | O43295 |
| Molecular Weight: | 1099 |
| NCBI Full Name: | SLIT-ROBO Rho GTPase-activating protein 3 |
| NCBI Synonym Full Names: | SLIT-ROBO Rho GTPase activating protein 3 |
| NCBI Official Symbol: | SRGAP3 |
| NCBI Official Synonym Symbols: | WRP; MEGAP; SRGAP2; ARHGAP14 |
| NCBI Protein Information: | SLIT-ROBO Rho GTPase-activating protein 3; mental disorder-associated GAP; rho GTPase-activating protein 14; SLIT-ROBO Rho GTPase activating protein 2; WAVE-associated Rac GTPase activating protein |
| UniProt Protein Name: | SLIT-ROBO Rho GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | Mental disorder-associated GAP; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP |
| Protein Family: | SLIT-ROBO Rho GTPase-activating protein |
| UniProt Gene Name: | SRGAP3 |
| UniProt Entry Name: | SRGP3_HUMAN |
| Antibodies |
| SRGAP3 Antibody (PACO12458) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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