SQSTM1 Polyclonal Antibody
- SKU:
- CAB22025
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | SQSTM1 Polyclonal Antibody |
| Product Code: | CAB22025 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, 293T, PC-12, C2C12+chloroquine |
| Cellular Location: | amphisome, autophagosome, cytoplasm, cytosol, endoplasmic reticulum, late endosome, mitochondrion, P-body, PML body, sarcomere |
Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation; energy homeostasis; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1).
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of mouse SQSTM1 (NP_035148.1). |
| Sequence: | PLGIE VDIDV EHGGK RSRLT PTTPE SSSTG TEDKS NTQPS SCSSE VSKPD GAGEG PAQSL TEQMK KIALE SVGQP EEQME SGNCS GGDDD WTHLS SKEVD P |
| Synonyms: | Osi, p62, A170, STAP, OSF-6, STONE14 |
| Calculated MW: | 48kDa |
| Observed MW: | 62kDa |
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