SPRY2 Antibody (PACO50038)
- SKU:
- PACO50038
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SPRY2 Antibody (PACO50038) |
| Antibody SKU: | PACO50038 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human SPRY2 protein (2-97AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: NIH/3T3 whole cell lysate, Jurkat whole cell lysate, HEK293 whole cell lysate. All lanes: SPRY2 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO50038 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO50038 at dilution of 1:100. |
| Background: | May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. |
| Synonyms: | Protein sprouty homolog 2 (Spry-2), SPRY2 |
| UniProt Protein Function: | SPRY2: a feedback inhibitor of growth factor receptor signaling. Belongs to the sprouty family. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; InhibitorChromosomal Location of Human Ortholog: 13q31.1Cellular Component: microtubule cytoskeleton; microtubule; plasma membrane; cytosolMolecular Function: protein serine/threonine kinase inhibitor activity; protein serine/threonine kinase activator activity; protein binding; protein kinase bindingBiological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; sensory perception of sound; establishment of mitotic spindle orientation; negative regulation of Ras protein signal transduction; negative regulation of apoptosis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq] |
| UniProt Code: | Q7Z783 |
| NCBI GenInfo Identifier: | 2809400 |
| NCBI Gene ID: | 10253 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q7Z783,Q5T6Z7 |
| UniProt Related Accession: | Q7Z783,O43597, Q7Z783 |
| Molecular Weight: | 34,688 Da |
| NCBI Full Name: | Sprouty 2 |
| NCBI Synonym Full Names: | sprouty homolog 2 (Drosophila) |
| NCBI Official Symbol: | SPRY2 |
| NCBI Official Synonym Symbols: | hSPRY2; MGC23039 |
| NCBI Protein Information: | protein sprouty homolog 2; spry-2; sprouty 2; OTTHUMP00000018543 |
| UniProt Protein Name: | Protein sprouty homolog 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein sprouty |
| UniProt Gene Name: | SPRY2 |
| UniProt Entry Name: | SPY2_HUMAN |
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