SPRN Antibody (PACO18390)
- SKU:
- PACO18390
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SPRN Antibody (PACO18390) |
| Antibody SKU: | PACO18390 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SPRN |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18390(SPRN Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18390(SPRN Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | SPRN (shadow of prion protein), also known as SHO or SHADOO, is a 151 amino acid, cytoplasmic protein that is mainly expressed in brain. SPRN is considered a prion-like protein that has PrP(C)-like neuroprotective activity and may act as a modulator for the biological actions of normal and abnormal PrP. In humans, mutations in the gene encoding SPRN may be associated with variant and sporadic Creutzfeldt-Jakob disease, a degenerative neurological disorder that is incurable and invariably fatal. |
| Synonyms: | shadow of prion protein homolog (zebrafish) |
| UniProt Protein Function: | SPRN: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. Belongs to the SPRN family.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 10q26.3 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5BIV9 |
| NCBI GenInfo Identifier: | 74722519 |
| NCBI Gene ID: | 503542 |
| NCBI Accession: | Q5BIV9.1 |
| UniProt Secondary Accession: | Q5BIV9 |
| UniProt Related Accession: | Q5BIV9 |
| Molecular Weight: | 14,522 Da |
| NCBI Full Name: | Shadow of prion protein |
| NCBI Synonym Full Names: | shadow of prion protein homolog (zebrafish) |
| NCBI Official Symbol: | SPRN |
| NCBI Official Synonym Symbols: | SHO; SHADOO; bA108K14.1 |
| NCBI Protein Information: | shadow of prion protein |
| UniProt Protein Name: | Shadow of prion protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Shadow of prion protein |
| UniProt Gene Name: | SPRN |
| UniProt Entry Name: | SPRN_HUMAN |
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