SPOPL Antibody (PACO57988)
- SKU:
- PACO57988
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SPOPL Antibody (PACO57988) |
| Antibody SKU: | PACO57988 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Speckle-type POZ protein-like protein (1-120AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A549 whole cell lysate. All lanes: SPOPL antibody at 6.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa. |
| Background: | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. |
| Synonyms: | Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2), SPOPL |
| UniProt Protein Function: | SPOPL: In complex with a cullin, may act in ubiquitination and proteasomal degradation processes. Belongs to the Tdpoz family.Protein type: Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 2q22.1Molecular Function: protein bindingBiological Process: negative regulation of protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6IQ16 |
| NCBI GenInfo Identifier: | 74736582 |
| NCBI Gene ID: | 339745 |
| NCBI Accession: | Q6IQ16.1 |
| UniProt Secondary Accession: | Q6IQ16 |
| UniProt Related Accession: | Q6IQ16 |
| Molecular Weight: | 44,647 Da |
| NCBI Full Name: | Speckle-type POZ protein-like |
| NCBI Synonym Full Names: | speckle type BTB/POZ protein like |
| NCBI Official Symbol: | SPOPL |
| NCBI Official Synonym Symbols: | BTBD33 |
| NCBI Protein Information: | speckle-type POZ protein-like |
| UniProt Protein Name: | Speckle-type POZ protein-like |
| UniProt Synonym Protein Names: | HIB homolog 2; Roadkill homolog 2 |
| Protein Family: | Speckle-type POZ protein |
| UniProt Gene Name: | SPOPL |
| UniProt Entry Name: | SPOPL_HUMAN |
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