Name: SPIC Antibody (PACO37934)
SKU: PACO37934
Availability: OutOfStock

Antibody Name:	SPIC Antibody (PACO37934)
Antibody SKU:	PACO37934
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human Transcription factor Spi-C protein (1-248AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry of paraffin-embedded human breast cancer using PACO37934 at dilution of 1:100.
	Western Blot. Positive WB detected in: Mouse heart tissue, Mouse liver tissue. All lanes: SPIC antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa.
	Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO37934 at dilution of 1:100.

Background:	Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
Synonyms:	Transcription factor Spi-C, SPIC

UniProt Protein Function:	SPIC: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Belongs to the ETS family.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 12q23.2 Cellular Component: nucleus Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter
NCBI Summary:	The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
UniProt Code:	Q8N5J4
NCBI GenInfo Identifier:	22748707
NCBI Gene ID:	121599
NCBI Accession:	NP_689536.1
UniProt Related Accession:	Q8N5J4
Molecular Weight:	29kd
NCBI Full Name:	transcription factor Spi-C
NCBI Synonym Full Names:	Spi-C transcription factor
NCBI Official Symbol:	SPIC
NCBI Official Synonym Symbols:	SPI-C
NCBI Protein Information:	transcription factor Spi-C
UniProt Protein Name:	Transcription factor Spi-C
Protein Family:	SpiC
UniProt Gene Name:	SPIC
UniProt Entry Name:	SPIC_HUMAN

Antibodies	ELISA Kits
SPIC Antibody (PACO01529)	SPIC Transcription Factor Activity Assay

Secondary Antibody

Neuroimmunologie: Das Immunsystem des ZNS

Interleukin-8-Signalisierung