SPHK1 Monoclonal Antibody
- SKU:
- CAB22093
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | SPHK1 Monoclonal Antibody |
| Product Code: | CAB22093 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54487 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HepG2, Hela |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus |
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SPHK1 (NP_001136074.1). |
| Sequence: | MDPAG GPRGV LPRPC RVLVL LNPRG GKGKA LQLFR SHVQP LLAEA EISFT LMLTE RRNHA RELVR SEELG RWDAL VVMSG DGLMH EVVNG LMERP DWETA IQKPL CSLPA GSGNA LAASL NHYAG YEQVT NEDLL TNCTL LLCRR LLSPM NLLSL HTASG |
| Synonyms: | SPHK |
| Calculated MW: | 43kDa |
| Observed MW: | 45-60kDa |
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