speB Antibody (PACO50626)
- SKU:
- PACO50626
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Streptococcus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | speB Antibody (PACO50626) |
| Antibody SKU: | PACO50626 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Streptococcus pyogenes serotype M28 |
| Immunogen: | Recombinant Streptococcus pyogenes serotype M28 Streptopain protein (146-398AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: speB antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa.. |
| Background: | Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing (By similarity). |
| Synonyms: | Streptopain (EC 3.4.22.10) (Exotoxin type B) (SPE B) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP), speB |
| UniProt Protein Function: | Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q48R29 |
| NCBI GenInfo Identifier: | 499604501 |
| NCBI Gene ID: | |
| NCBI Accession: | WP_011285235.1 |
| UniProt Secondary Accession: | Q48R29 |
| UniProt Related Accession: | Q48R29 |
| Molecular Weight: | 43.6 kDa |
| NCBI Full Name: | streptopain |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Streptopain |
| UniProt Synonym Protein Names: | Exotoxin type B; SPE B; Streptococcal cysteine proteinase; Streptococcus peptidase A; SPP |
| Protein Family: | Streptopain |
| UniProt Gene Name: | speB |
| UniProt Entry Name: | SPEB_STRPM |
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