| UniProt Protein Function: | CCDC99: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Belongs to the Spindly family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 5q35.1Cellular Component: cytosol; nucleus; outer kinetochore of condensed chromosome; spindle poleMolecular Function: enzyme binding; kinetochore binding; protein bindingBiological Process: establishment of mitotic spindle orientation; mitotic metaphase plate congression; sister chromatid cohesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q96EA4 |
| NCBI GenInfo Identifier: | 296452913 |
| NCBI Gene ID: | 54908 |
| NCBI Accession: | Q96EA4.2 |
| UniProt Secondary Accession: | Q96EA4,Q8TEC8, Q9HD44, Q9NX97, B4E393, C9JS47 |
| UniProt Related Accession: | Q96EA4 |
| Molecular Weight: | 61,015 Da |
| NCBI Full Name: | Protein Spindly |
| NCBI Synonym Full Names: | spindle apparatus coiled-coil protein 1 |
| NCBI Official Symbol: | SPDL1 |
| NCBI Official Synonym Symbols: | CCDC99 |
| NCBI Protein Information: | protein Spindly |
| UniProt Protein Name: | Protein Spindly |
| UniProt Synonym Protein Names: | Arsenite-related gene 1 protein; Coiled-coil domain-containing protein 99 |
| Protein Family: | Protein Spindly |
| UniProt Gene Name: | SPDL1 |
| UniProt Entry Name: | SPDLY_HUMAN |
