SPATA18 Antibody (PACO20590)
- SKU:
- PACO20590
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SPATA18 Antibody (PACO20590) |
| Antibody SKU: | PACO20590 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SPATA18 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20590(SPATA18 Antibody) at dilution 1/250 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20590(SPATA18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | SPATA18 (spermatogenesis associated 18), also known as Mieap or SPETEX1, is a 538 amino acid, protein that is thought to play a role in cell differentiation during spermatogenesis, particularly during development from late elongate spematids to mature spermatozoa. Localizing to cytoplasm, SPATA18 is encoded by a gene that maps to human chromosome 4q12. |
| Synonyms: | spermatogenesis associated 18 |
| UniProt Protein Function: | SPATA18: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Belongs to the MIEAP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 4q12Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; cytoplasmMolecular Function: protein bindingBiological Process: response to DNA damage stimulus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8TC71 |
| NCBI GenInfo Identifier: | 74751399 |
| NCBI Gene ID: | 132671 |
| NCBI Accession: | Q8TC71.1 |
| UniProt Secondary Accession: | Q8TC71,Q8IY48, Q8N7D7, B4E2R0, E5RLK1 |
| UniProt Related Accession: | Q8TC71 |
| Molecular Weight: | 57,485 Da |
| NCBI Full Name: | Mitochondria-eating protein |
| NCBI Synonym Full Names: | spermatogenesis associated 18 |
| NCBI Official Symbol: | SPATA18 |
| NCBI Official Synonym Symbols: | Mieap; SPETEX1 |
| NCBI Protein Information: | mitochondria-eating protein; spermatogenesis associated 18 homolog; spermatogenesis-associated protein 18 |
| UniProt Protein Name: | Mitochondria-eating protein |
| UniProt Synonym Protein Names: | Spermatogenesis-associated protein 18 |
| Protein Family: | Mitochondria-eating protein |
| UniProt Gene Name: | SPATA18 |
| UniProt Entry Name: | MIEAP_HUMAN |
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