SPATA13 Antibody (PACO15057)
- SKU:
- PACO15057
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SPATA13 Antibody (PACO15057) |
| Antibody SKU: | PACO15057 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human SPATA13 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15057(SPATA13 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO15057(SPATA13 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15057(SPATA13 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity. |
| Synonyms: | Spermatogenesis associated 13 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96N96 |
| NCBI GenInfo Identifier: | 23308553 |
| NCBI Gene ID: | 221178 |
| NCBI Accession: | NP_694568.1 |
| UniProt Secondary Accession: | Q96N96,Q5VX68, Q6ZML1, Q8N873, Q8TEK6, A2VEA9, A6NF85 B4DQB1, B4DSZ0, B4DVM8 |
| UniProt Related Accession: | Q96N96 |
| Molecular Weight: | 141,436 Da |
| NCBI Full Name: | spermatogenesis-associated protein 13 isoform 2 |
| NCBI Synonym Full Names: | spermatogenesis associated 13 |
| NCBI Official Symbol: | SPATA13 |
| NCBI Official Synonym Symbols: | ASEF2; ARHGEF29 |
| NCBI Protein Information: | spermatogenesis-associated protein 13 |
| UniProt Protein Name: | Spermatogenesis-associated protein 13 |
| UniProt Synonym Protein Names: | APC-stimulated guanine nucleotide exchange factor 2; Asef2 |
| Protein Family: | |
| UniProt Gene Name: | SPATA13 |
| UniProt Entry Name: | SPT13_HUMAN |
| Antibodies |
| SPATA13 Antibody (PACO12422) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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