SPAG9 Antibody (PACO46226)
- SKU:
- PACO46226
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SPAG9 Antibody (PACO46226) |
| Antibody SKU: | PACO46226 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human C-Jun-amino-terminal kinase-interacting protein 4 protein (209-259AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO46226 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO46226 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO46226 at dilution of 1:100. |
| Background: | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction. |
| Synonyms: | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1), SPAG9, HSS KIAA0516 MAPK8IP4 SYD1 |
| UniProt Protein Function: | JIP4: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 17q21.33 Cellular Component: cytoplasm; cytosol; integral to membrane; microtubule organizing center Molecular Function:JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; protein binding; receptor signaling complex scaffold activity Biological Process: activation of JNK activity; positive regulation of cell migration; positive regulation of muscle cell differentiation; retrograde transport, endosome to Golgi; spermatogenesis |
| NCBI Summary: | This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O60271 |
| NCBI GenInfo Identifier: | 94717648 |
| NCBI Gene ID: | 9043 |
| NCBI Accession: | O60271.4 |
| UniProt Secondary Accession: | O60271,O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7 Q96II0, Q9H811, A6H8U5, A8MSX0, B4DHH2, |
| UniProt Related Accession: | O60271 |
| Molecular Weight: | 128,607 Da |
| NCBI Full Name: | C-Jun-amino-terminal kinase-interacting protein 4 |
| NCBI Synonym Full Names: | sperm associated antigen 9 |
| NCBI Official Symbol: | SPAG9 |
| NCBI Official Synonym Symbols: | JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4 |
| NCBI Protein Information: | C-Jun-amino-terminal kinase-interacting protein 4 |
| UniProt Protein Name: | C-Jun-amino-terminal kinase-interacting protein 4 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 89; CT89; Human lung cancer oncogene 6 protein; HLC-6; JNK-associated leucine-zipper protein; JLP; Mitogen-activated protein kinase 8-interacting protein 4; Proliferation-inducing protein 6; Protein highly expressed in testis; PHET; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1 |
| Protein Family: | C-Jun-amino-terminal kinase-interacting protein |
| UniProt Gene Name: | SPAG9 |
| UniProt Entry Name: | JIP4_HUMAN |
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