SP3/SP4 Antibody (PACO05110)
- SKU:
- PACO05110
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SP3/SP4 Antibody (PACO05110) |
| Antibody SKU: | PACO05110 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human Sp3/4. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SP3; Transcription factor Sp3; SPR-2; SP4; Transcription factor Sp4; SPR-1 |
| UniProt Protein Function: | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. |
| NCBI Summary: | This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q02447 |
| NCBI GenInfo Identifier: | 30923147 |
| NCBI Gene ID: | 6670 |
| NCBI Accession: | Q02447.3 |
| UniProt Secondary Accession: | Q02447,Q69B26, Q69B27, Q8TD56, Q8WWU4, Q9BQR1, A0AVL9 B4E2B7, |
| UniProt Related Accession: | Q02447 |
| Molecular Weight: | 76,814 Da |
| NCBI Full Name: | Transcription factor Sp3 |
| NCBI Synonym Full Names: | Sp3 transcription factor |
| NCBI Official Symbol: | SP3 |
| NCBI Official Synonym Symbols: | SPR2 |
| NCBI Protein Information: | transcription factor Sp3 |
| UniProt Protein Name: | Transcription factor Sp3 |
| UniProt Synonym Protein Names: | SPR-2 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SP3 |
| UniProt Entry Name: | SP3_HUMAN |
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