Name: SOX8 Antibody (PACO18909)
SKU: PACO18909
Availability: OutOfStock

Antibody Name:	SOX8 Antibody (PACO18909)
Antibody SKU:	PACO18909
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human SOX8

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO18909(SOX8 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.

Background:

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).

Synonyms:

SRY (sex determining region Y)-box 8

UniProt Protein Function:	SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis
NCBI Summary:	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008]
UniProt Code:	P57073
NCBI GenInfo Identifier:	10720294
NCBI Gene ID:	30812
NCBI Accession:	P57073.1
UniProt Secondary Accession:	P57073,P48436, Q9H6I2, P35713,
UniProt Related Accession:	P57073
Molecular Weight:	446
NCBI Full Name:	Transcription factor SOX-8
NCBI Synonym Full Names:	SRY (sex determining region Y)-box 8
NCBI Official Symbol:	SOX8
NCBI Protein Information:	transcription factor SOX-8
UniProt Protein Name:	Transcription factor SOX-8
Protein Family:	Transcription factor
UniProt Gene Name:	SOX8
UniProt Entry Name:	SOX8_HUMAN