SOX8 Antibody (PACO12403)
- SKU:
- PACO12403
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SOX8 Antibody (PACO12403) |
| Antibody SKU: | PACO12403 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human SOX8 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SRY (sex determining region Y)-box 8;SOX8;MGC24837 ; |
| UniProt Protein Function: | SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57073 |
| NCBI GenInfo Identifier: | 10720294 |
| NCBI Gene ID: | 30812 |
| NCBI Accession: | P57073.1 |
| UniProt Secondary Accession: | P57073,P48436, Q9H6I2, P35713, |
| UniProt Related Accession: | P57073 |
| Molecular Weight: | 446 |
| NCBI Full Name: | Transcription factor SOX-8 |
| NCBI Synonym Full Names: | SRY (sex determining region Y)-box 8 |
| NCBI Official Symbol: | SOX8 |
| NCBI Protein Information: | transcription factor SOX-8 |
| UniProt Protein Name: | Transcription factor SOX-8 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX8 |
| UniProt Entry Name: | SOX8_HUMAN |
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