SOS2 Antibody (PACO63399)
- SKU:
- PACO63399
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SOS2 Antibody (PACO63399) |
| Antibody SKU: | PACO63399 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Son of sevenless homolog 2 protein (187-404AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A549 whole cell lysate, SH-SY5Y whole cell lysate, HL60 whole cell lysate, K562 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate. All lanes: SOS2 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 153, 150 kDa. Observed band size: 153 kDa. |
 | IHC image of PACO63399 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO63399 diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Promotes the exchange of Ras-bound GDP by GTP. |
| Synonyms: | Son of sevenless homolog 2 (SOS-2), SOS2 |
| UniProt Protein Function: | SOS2: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2.Protein type: Motility/polarity/chemotaxis; GEFs, Ras; GEFs; Adaptor/scaffoldChromosomal Location of Human Ortholog: 14q21Cellular Component: cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activityBiological Process: positive regulation of small GTPase mediated signal transduction; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q07890 |
| NCBI GenInfo Identifier: | 154689780 |
| NCBI Gene ID: | 6655 |
| NCBI Accession: | NP_008870.2 |
| UniProt Secondary Accession: | Q07890,Q15503, Q17RN1, D3DSB4 |
| UniProt Related Accession: | Q07890 |
| Molecular Weight: | 152,979 Da |
| NCBI Full Name: | son of sevenless homolog 2 |
| NCBI Synonym Full Names: | son of sevenless homolog 2 (Drosophila) |
| NCBI Official Symbol: | SOS2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | son of sevenless homolog 2; SOS-2; guanine nucleotide exchange factor; guanine nucleotide releasing factor |
| UniProt Protein Name: | Son of sevenless homolog 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Son of sevenless |
| UniProt Gene Name: | SOS2 |
| UniProt Entry Name: | SOS2_HUMAN |
| Antibodies |
| SOS2 Antibody (PACO05105) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-SOS2 Antibody (CAB20292)
OverviewProduct Name:SOS2 Rabbit pAbProduct Code:CAB20292Size:50uL, 100uLSynonyms:ATSOS2, CBL-INTERACTING PROTEIN KINASE 24, CIPK24, K21
SPEF2 Antibody
Overview Product Name:SPEF2 AntibodyProduct Code:PACO64977Size:50µLTarget Names:SPEF2Species Reactivity:HumanHos
ompF Antibody
Overview Product Name:ompF AntibodyProduct Code:PACO64865Size:50µLTarget Names:ompFSpecies Reactivity:Escherichia coli