Sort1 Antibody (PACO30088)
- SKU:
- PACO30088
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Sort1 Antibody (PACO30088) |
| Antibody SKU: | PACO30088 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Sortilin protein (610-754AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. |
| Synonyms: | Sortilin (Glycoprotein 110) (Gp110) (Neurotensin receptor 3) (NTR3), Sort1 |
| UniProt Protein Function: | SORT1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. Belongs to the VPS10-related sortilin family. SORT1 subfamily.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 2q34Cellular Component: cell soma; cell surface; clathrin-coated vesicle; coated pit; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; early endosome; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network transport vesicleMolecular Function: enzyme binding; nerve growth factor binding; nerve growth factor receptor activity; neurotensin receptor activity, G-protein coupled; neurotensin receptor activity, non-G-protein coupledBiological Process: endocytosis; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; G-protein coupled receptor protein signaling pathway; glucose import; Golgi to endosome transport; induction of apoptosis via death domain receptors; myotube differentiation; negative regulation of fat cell differentiation; negative regulation of lipoprotein lipase activity; nerve growth factor receptor signaling pathway; neuropeptide signaling pathway; plasma membrane to endosome transport; regulation of gene expression; response to insulin stimulus; vesicle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | may be involved in sorting lumenal proteins in the trans-Golgi [RGD, Feb 2006] |
| UniProt Code: | O54861 |
| NCBI GenInfo Identifier: | 209954677 |
| NCBI Gene ID: | 83576 |
| NCBI Accession: | NP_113955.1 |
| UniProt Secondary Accession: | O54861,O35389 |
| UniProt Related Accession: | O54861 |
| Molecular Weight: | 32.5kD |
| NCBI Full Name: | sortilin |
| NCBI Synonym Full Names: | sortilin 1 |
| NCBI Official Symbol: | Sort1 |
| NCBI Official Synonym Symbols: | Nt3; Nts3 |
| NCBI Protein Information: | sortilin |
| UniProt Protein Name: | Sortilin |
| UniProt Synonym Protein Names: | Glycoprotein 110; Gp110; Neurotensin receptor 3; NTR3 |
| Protein Family: | Sortilin |
| UniProt Gene Name: | Sort1 |
| UniProt Entry Name: |
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