Sorbitol Dehydrogenase Polyclonal Antibody

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SKU:
CAB22009
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:Sorbitol Dehydrogenase Polyclonal Antibody
Product Code:CAB22009
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Mouse kidney, Mouse liver, Rat liver
Cellular Location:cytosol, extracellular exosome, extracellular space, mitochondrial membrane

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Sorbitol Dehydrogenase (NP_003095.2).
Sequence:RENDE FCKMG RYNLS PSIFF CATPP DDGNL CRFYK HNAAF CYKLP DNVTF EEGAL IEPLS VGIHA CRRGG VTLGH KVLVC GAGPI GMVTL LVAKA MGAAQ V
Synonyms:RDH, SDH, XDH, SORD1, SORDD, HEL-S-95n
Calculated MW:38kDa
Observed MW:38kDa
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