SOCS3 Monoclonal Antibody
- SKU:
- CAB21981
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | SOCS3 Monoclonal Antibody |
| Product Code: | CAB21981 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53312 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | RAW 264.7+LPS, 293T-SOCS3-Flag |
| Cellular Location: | Cytosol |
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 126-225 of human SOCS3 (NP_003946.3). |
| Sequence: | HYMPP PGAPS FPSPP TEPSS EVPEQ PSAQP LPGSP PRRAY YIYSG GEKIP LVLSR PLSSN VATLQ HLCRK TVNGH LDSYE KVTQL PGPIR EFLDQ YDAPL |
| Synonyms: | CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3 |
| Calculated MW: | 25kDa |
| Observed MW: | 28kDa |
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