SNX8 Antibody (PACO17139)
- SKU:
- PACO17139
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SNX8 Antibody (PACO17139) |
| Antibody SKU: | PACO17139 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human SNX8 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17139(SNX8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17139(SNX8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX8 is an ortholog of a yeast protein. |
| Synonyms: | sorting nexin 8 |
| UniProt Protein Function: | SNX8: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. Belongs to the sorting nexin family.Chromosomal Location of Human Ortholog: 7p22.3Cellular Component: early endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; retromer complexMolecular Function: identical protein binding; phosphoinositide binding; protein bindingBiological Process: endocytosis; intracellular protein transport; vesicle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y5X2 |
| NCBI GenInfo Identifier: | 10720288 |
| NCBI Gene ID: | 29886 |
| NCBI Accession: | Q9Y5X2.1 |
| UniProt Secondary Accession: | Q9Y5X2,Q96I67, A4D207 |
| UniProt Related Accession: | Q9Y5X2 |
| Molecular Weight: | 52,569 Da |
| NCBI Full Name: | Sorting nexin-8 |
| NCBI Synonym Full Names: | sorting nexin 8 |
| NCBI Official Symbol: | SNX8 |
| NCBI Official Synonym Symbols: | Mvp1 |
| NCBI Protein Information: | sorting nexin-8 |
| UniProt Protein Name: | Sorting nexin-8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX8 |
| UniProt Entry Name: | SNX8_HUMAN |
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