SNX33 Antibody (PACO60296)
- SKU:
- PACO60296
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SNX33 Antibody (PACO60296) |
| Antibody SKU: | PACO60296 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sorting nexin-33 protein (348-516AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60296 diluted at 1:800 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. |
| Synonyms: | Sorting nexin-33 (SH3 and PX domain-containing protein 3), SNX33, SH3PX3 SH3PXD3C SNX30 |
| UniProt Protein Function: | SNX33: Belongs to the sorting nexin family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 15q24.2Cellular Component: cytoplasmic membrane-bound vesicle; cytosol; endosome; extrinsic to membrane; membraneMolecular Function: identical protein binding; phosphoinositide binding; protein bindingBiological Process: cytokinesis after mitosis; endocytosis; endosome organization and biogenesis; endosome transport; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; protein import; vesicle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q8WV41 |
| NCBI GenInfo Identifier: | 74751538 |
| NCBI Gene ID: | 257364 |
| NCBI Accession: | Q8WV41.1 |
| UniProt Secondary Accession: | Q8WV41,B1NM17 |
| UniProt Related Accession: | Q8WV41 |
| Molecular Weight: | 65,265 Da |
| NCBI Full Name: | Sorting nexin-33 |
| NCBI Synonym Full Names: | sorting nexin 33 |
| NCBI Official Symbol: | SNX33 |
| NCBI Official Synonym Symbols: | SNX30; SH3PX3; SH3PXD3C |
| NCBI Protein Information: | sorting nexin-33 |
| UniProt Protein Name: | Sorting nexin-33 |
| UniProt Synonym Protein Names: | SH3 and PX domain-containing protein 3 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX33 |
| UniProt Entry Name: | SNX33_HUMAN |
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