SNX10 Antibody (PACO60448)
- SKU:
- PACO60448
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SNX10 Antibody (PACO60448) |
| Antibody SKU: | PACO60448 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sorting nexin-10 protein (124-201AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60448 diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. |
| Synonyms: | Sorting nexin-10, SNX10 |
| UniProt Protein Function: | SNX10: May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Overexpression causes formation of huge vacuoles. Belongs to the sorting nexin family.Chromosomal Location of Human Ortholog: 7p15.2Cellular Component: centrosome; endoplasmic reticulum; nucleusMolecular Function: ATPase binding; phosphatidylinositol bindingBiological Process: protein transport; endosome organization and biogenesis; vesicle organization and biogenesis; cilium biogenesis; endocytosis; osteoclast differentiationDisease: Osteopetrosis, Autosomal Recessive 8 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9Y5X0 |
| NCBI GenInfo Identifier: | 315360660 |
| NCBI Gene ID: | 29887 |
| NCBI Accession: | NP_001186764.1 |
| UniProt Secondary Accession: | Q9Y5X0,Q8IYT5, E9PFH5 |
| UniProt Related Accession: | Q9Y5X0 |
| Molecular Weight: | 23,598 Da |
| NCBI Full Name: | sorting nexin-10 isoform 1 |
| NCBI Synonym Full Names: | sorting nexin 10 |
| NCBI Official Symbol: | SNX10 |
| NCBI Official Synonym Symbols: | OPTB8 |
| NCBI Protein Information: | sorting nexin-10 |
| UniProt Protein Name: | Sorting nexin-10 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX10 |
| UniProt Entry Name: | SNX10_HUMAN |
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