Snaclec rhodocytin subunit alpha Antibody (PACO53938)
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- SKU:
- PACO53938
- Product Type:
- Antibody
- Reactivity:
- Snake
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Snaclec rhodocytin subunit α Antibody (PACO53938) |
| Antibody SKU: | PACO53938 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Calloselasma rhodostoma |
| Immunogen: | Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit α protein (1-136AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: Rhodocytin subunit alpha antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 31 kDa. Observed band size: 31 kDa. |
| Background: | Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbα (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. |
| Synonyms: | Snaclec rhodocytin subunit α (Aggretin α chain) (Rhodoaggretin subunit alpha) |
| UniProt Protein Function: | Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9I841 |
| NCBI GenInfo Identifier: | 82174508 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9I841.1 |
| UniProt Secondary Accession: | Q9I841 |
| UniProt Related Accession: | Q9I841 |
| Molecular Weight: | 15,796 Da |
| NCBI Full Name: | Snaclec rhodocytin subunit alpha |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Snaclec rhodocytin subunit alpha |
| UniProt Synonym Protein Names: | Aggretin alpha chain; Rhodoaggretin subunit alpha |
| Protein Family: | Snaclec rhodocytin |
| UniProt Gene Name: | |
| UniProt Entry Name: |
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