SMG8 Antibody (PACO18645)
- SKU:
- PACO18645
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SMG8 Antibody (PACO18645) |
| Antibody SKU: | PACO18645 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human SMG8 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18645(SMG8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18645(SMG8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. |
| Synonyms: | SMG8 nonsense mediated mRNA decay factor |
| UniProt Protein Function: | SMG8: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. Belongs to the SMG8 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: RNA processingChromosomal Location of Human Ortholog: 17q22Cellular Component: cytosolMolecular Function: protein bindingBiological Process: mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of protein kinase activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8ND04 |
| NCBI GenInfo Identifier: | 47777319 |
| NCBI Gene ID: | 55181 |
| NCBI Accession: | NP_060619.4 |
| UniProt Secondary Accession: | Q8ND04,Q8N5U5, Q8TDN0, Q9H5P5, Q9NVQ1 |
| UniProt Related Accession: | Q8ND04 |
| Molecular Weight: | 65,088 Da |
| NCBI Full Name: | protein SMG8 |
| NCBI Synonym Full Names: | SMG8 nonsense mediated mRNA decay factor |
| NCBI Official Symbol: | SMG8 |
| NCBI Official Synonym Symbols: | C17orf71 |
| NCBI Protein Information: | protein SMG8 |
| UniProt Protein Name: | Protein SMG8 |
| UniProt Synonym Protein Names: | Amplified in breast cancer gene 2 protein; Protein smg-8 homolog |
| Protein Family: | Protein |
| UniProt Gene Name: | SMG8 |
| UniProt Entry Name: | SMG8_HUMAN |
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