SMARCA2 / BRM Monoclonal Antibody
- SKU:
- CAB23291
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | SMARCA2 / BRM Monoclonal Antibody |
| Product Code: | CAB23291 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59944 |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200, IP 1:2000-1:6000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | nucleus |
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 201-300 of human SMARCA2 (NP_003061.3). |
| Sequence: | TLQLA VQGKR TLPGL QQQQQ QQQQQ QQQQQ QQQQQ QQQPQ QQPPQ PQTQQ QQQPA LVNYN RPSGP GPELS GPSTP QKLPV PAPGG RPSPA PPAAA QPPAA |
| Synonyms: | BIS, BRM, SNF2, SWI2, hBRM, NCBRS, Sth1p, BAF190, SNF2L2, SNF2LA, hSNF2a |
| Calculated MW: | 181kDa |
| Observed MW: | 220kDa |
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