Smad1 Monoclonal Antibody (CAB22326)
- SKU:
- CAB22326
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
Description
| Product Name: | Smad1 Monoclonal Antibody |
| Product Code: | CAB22326 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52106 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Mouse lung, Mouse brain |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human Smad1 (NP_005891.1). |
| Sequence: | WKQGD EEEKW AEKAV DALVK KLKKK KGAME ELEKA LSCPG QPSNC VTIPR SLDGR LQVSH RKGLP HVIYC RVWRW PDLQS HHELK PLECC EFPFG SKQKE VCINP YHYKR VESPV LPPVL VPRHS EYNPQ HSLLA QFRNL GQNEP HMPLN ATFPD SFQQP NSHPF PHSPN SSYPN SPGSS SSTYP HSPTS SDPGS PFQMP ADTPP PAYLP PEDPM TQDGS Q |
| Synonyms: | BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1 |
| Calculated MW: | 52kDa |
| Observed MW: | 60kDa |
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