SLCO1B3 Antibody (PACO48758)
- SKU:
- PACO48758
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLCO1B3 Antibody (PACO48758) |
| Antibody SKU: | PACO48758 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Solute carrier organic anion transporter family member 1B3 protein (648-695AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO48758 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO48758 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO48758 at dilution of 1:100. |
| Background: | Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acid, and organic anions from the liver. |
| Synonyms: | Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8), SLCO1B3, LST2 OATP1B3 OATP8 SLC21A8 |
| UniProt Protein Function: | SLCO1B3: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; TransporterChromosomal Location of Human Ortholog: 12p12Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: bile acid transmembrane transporter activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activityBiological Process: bile acid and bile salt transport; bile acid metabolic process; organic anion transport; sodium-independent organic anion transportDisease: Hyperbilirubinemia, Rotor Type |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9NPD5 |
| NCBI GenInfo Identifier: | 27734563 |
| NCBI Gene ID: | 28234 |
| NCBI Accession: | Q9NPD5.1 |
| UniProt Secondary Accession: | Q9NPD5,Q5JAR4, E7EMT8 |
| UniProt Related Accession: | Q9NPD5 |
| Molecular Weight: | 82,544 Da |
| NCBI Full Name: | Solute carrier organic anion transporter family member 1B3 |
| NCBI Synonym Full Names: | solute carrier organic anion transporter family member 1B3 |
| NCBI Official Symbol: | SLCO1B3 |
| NCBI Official Synonym Symbols: | LST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13 |
| NCBI Protein Information: | solute carrier organic anion transporter family member 1B3 |
| UniProt Protein Name: | Solute carrier organic anion transporter family member 1B3 |
| UniProt Synonym Protein Names: | Liver-specific organic anion transporter 2; LST-2; Organic anion transporter 8; Organic anion-transporting polypeptide 8; OATP-8; Solute carrier family 21 member 8 |
| Protein Family: | Solute carrier organic anion transporter family |
| UniProt Gene Name: | SLCO1B3 |
| UniProt Entry Name: | SO1B3_HUMAN |
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