SLC9A3R2 Antibody (PACO20535)
- SKU:
- PACO20535
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC9A3R2 Antibody (PACO20535) |
| Antibody SKU: | PACO20535 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Synthetic peptide of human SLC9A3R2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20535(SLC9A3R2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Synonyms: | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 |
| UniProt Protein Function: | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. |
| NCBI Summary: | This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q15599 |
| NCBI GenInfo Identifier: | 194018553 |
| NCBI Gene ID: | 9351 |
| NCBI Accession: | NP_001123484.1 |
| UniProt Secondary Accession: | Q15599,O00272, O00556, Q3KQY7, D3DU84, D3DU85, H3BSV6 |
| UniProt Related Accession: | Q15599 |
| Molecular Weight: | 24,718 Da |
| NCBI Full Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform a |
| NCBI Synonym Full Names: | SLC9A3 regulator 2 |
| NCBI Official Symbol: | SLC9A3R2 |
| NCBI Official Synonym Symbols: | SIP1; OCTS2; SIP-1; TKA-1; E3KARP; NHERF2; NHE3RF2; NHERF-2 |
| NCBI Protein Information: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| UniProt Protein Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| UniProt Synonym Protein Names: | NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 |
| UniProt Gene Name: | SLC9A3R2 |
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