Name: SLC8B1 Antibody (PACO20486)
SKU: PACO20486
Availability: OutOfStock

Antibody Name:	SLC8B1 Antibody (PACO20486)
Antibody SKU:	PACO20486
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human SLC8B1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20486(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane 1-2: Human placenta tissue, Human normal kidney tissue,Primary antibody: PACO20486(SLC8B1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20486(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion.
Synonyms:	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

UniProt Protein Function:	Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
UniProt Protein Details:
NCBI Summary:	SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
UniProt Code:	Q6J4K2
NCBI GenInfo Identifier:	1060099165
NCBI Gene ID:	80024
NCBI Accession:	NP_001317395.1
UniProt Secondary Accession:	Q6J4K2,Q4KMS9, Q6J4K1, Q9H6I8, A6NP50
UniProt Related Accession:	Q6J4K2
Molecular Weight:	58,087 Da
NCBI Full Name:	mitochondrial sodium/calcium exchanger protein isoform 2
NCBI Synonym Full Names:	solute carrier family 8 member B1
NCBI Official Symbol:	SLC8B1
NCBI Official Synonym Symbols:	NCLX; NCKX6; SLC24A6
NCBI Protein Information:	mitochondrial sodium/calcium exchanger protein
UniProt Protein Name:	Mitochondrial sodium/calcium exchanger protein
UniProt Synonym Protein Names:	Na(+)/K(+)/Ca(2+)-exchange protein 6
Protein Family:
UniProt Gene Name:	SLC8B1
UniProt Entry Name: