Name: SLC52A1 Antibody (PACO41442)
SKU: PACO41442
Availability: OutOfStock

Antibody Name:	SLC52A1 Antibody (PACO41442)
Antibody SKU:	PACO41442
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human Solute carrier family 52, riboflavin transporter, member 1 protein (212-279AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO41442 at dilution of 1:100.
	Immunofluorescent analysis of HepG2 cells using PACO41442 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	Immunohistochemistry of paraffin-embedded human gastric cancer using PACO41442 at dilution of 1:100.

Background:	Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
Synonyms:	Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1), SLC52A1, GPR172B PAR2 RFT1

UniProt Protein Function:	GPR172B: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Haploinsufficiency in SLC52A1 can cause maternal riboflavin deficiency. In the newborn infant, this can lead to a transient riboflavin-responsive disorder with clinical and biochemical features of multiple acyl-CoA dehydrogenase deficiency. Belongs to the riboflavin transporter family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: integral to plasma membraneMolecular Function: riboflavin transporter activity; viral receptor activityBiological Process: entry of virus into host cell; riboflavin transportDisease: Riboflavin Deficiency
UniProt Protein Details:
NCBI Summary:	Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
UniProt Code:	Q9NWF4
NCBI GenInfo Identifier:	308153487
NCBI Gene ID:	55065
NCBI Accession:	Q9NWF4.2
UniProt Secondary Accession:	Q9NWF4,Q6P9E0, Q86UT0, B5MEV1, B5MEV2
UniProt Related Accession:	Q9NWF4
Molecular Weight:	16,360 Da
NCBI Full Name:	Solute carrier family 52, riboflavin transporter, member 1
NCBI Synonym Full Names:	solute carrier family 52 member 1
NCBI Official Symbol:	SLC52A1
NCBI Official Synonym Symbols:	PAR2; RFT1; RBFVD; RFVT1; hRFT1; GPCR42; GPR172B
NCBI Protein Information:	solute carrier family 52, riboflavin transporter, member 1
UniProt Protein Name:	Solute carrier family 52, riboflavin transporter, member 1
UniProt Synonym Protein Names:	Porcine endogenous retrovirus A receptor 2; PERV-A receptor 2; Protein GPR172B; Riboflavin transporter 1; hRFT1
Protein Family:	Solute carrier family
UniProt Gene Name:	SLC52A1
UniProt Entry Name:	S52A1_HUMAN