Antibody Name:	SLC52A1 Antibody (PACO19736)
Antibody SKU:	PACO19736
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human SLC52A1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19736(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19736(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms:

solute carrier family 52 (riboflavin transporter), member 1

UniProt Protein Function:	GPR172B: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Haploinsufficiency in SLC52A1 can cause maternal riboflavin deficiency. In the newborn infant, this can lead to a transient riboflavin-responsive disorder with clinical and biochemical features of multiple acyl-CoA dehydrogenase deficiency. Belongs to the riboflavin transporter family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: integral to plasma membraneMolecular Function: riboflavin transporter activity; viral receptor activityBiological Process: entry of virus into host cell; riboflavin transportDisease: Riboflavin Deficiency
UniProt Protein Details:
NCBI Summary:	Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
UniProt Code:	Q9NWF4
NCBI GenInfo Identifier:	308153487
NCBI Gene ID:	55065
NCBI Accession:	Q9NWF4.2
UniProt Secondary Accession:	Q9NWF4,Q6P9E0, Q86UT0, B5MEV1, B5MEV2
UniProt Related Accession:	Q9NWF4
Molecular Weight:	16,360 Da
NCBI Full Name:	Solute carrier family 52, riboflavin transporter, member 1
NCBI Synonym Full Names:	solute carrier family 52 member 1
NCBI Official Symbol:	SLC52A1
NCBI Official Synonym Symbols:	PAR2; RFT1; RBFVD; RFVT1; hRFT1; GPCR42; GPR172B
NCBI Protein Information:	solute carrier family 52, riboflavin transporter, member 1
UniProt Protein Name:	Solute carrier family 52, riboflavin transporter, member 1
UniProt Synonym Protein Names:	Porcine endogenous retrovirus A receptor 2; PERV-A receptor 2; Protein GPR172B; Riboflavin transporter 1; hRFT1
Protein Family:	Solute carrier family
UniProt Gene Name:	SLC52A1
UniProt Entry Name:	S52A1_HUMAN