SLC52A1 Antibody (PACO02991)
- SKU:
- PACO02991
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC52A1 Antibody |
| Antibody SKU: | PACO02991 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human GPR172B. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SLC52A1; GPR172B; PAR2; RFT1; Solute carrier family 52; riboflavin transporter, member 1; Porcine endogenous retrovirus A receptor 2; PERV-A receptor 2; Protein GPR172B; Riboflavin transporter 1; hRFT1 |
| UniProt Protein Function: | GPR172B: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Haploinsufficiency in SLC52A1 can cause maternal riboflavin deficiency. In the newborn infant, this can lead to a transient riboflavin-responsive disorder with clinical and biochemical features of multiple acyl-CoA dehydrogenase deficiency. Belongs to the riboflavin transporter family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: integral to plasma membraneMolecular Function: riboflavin transporter activity; viral receptor activityBiological Process: entry of virus into host cell; riboflavin transportDisease: Riboflavin Deficiency |
| UniProt Protein Details: | |
| NCBI Summary: | Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q9NWF4 |
| NCBI GenInfo Identifier: | 308153487 |
| NCBI Gene ID: | 55065 |
| NCBI Accession: | Q9NWF4.2 |
| UniProt Secondary Accession: | Q9NWF4,Q6P9E0, Q86UT0, B5MEV1, B5MEV2 |
| UniProt Related Accession: | Q9NWF4 |
| Molecular Weight: | 16,360 Da |
| NCBI Full Name: | Solute carrier family 52, riboflavin transporter, member 1 |
| NCBI Synonym Full Names: | solute carrier family 52 member 1 |
| NCBI Official Symbol: | SLC52A1 |
| NCBI Official Synonym Symbols: | PAR2; RFT1; RBFVD; RFVT1; hRFT1; GPCR42; GPR172B |
| NCBI Protein Information: | solute carrier family 52, riboflavin transporter, member 1 |
| UniProt Protein Name: | Solute carrier family 52, riboflavin transporter, member 1 |
| UniProt Synonym Protein Names: | Porcine endogenous retrovirus A receptor 2; PERV-A receptor 2; Protein GPR172B; Riboflavin transporter 1; hRFT1 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC52A1 |
| UniProt Entry Name: | S52A1_HUMAN |
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