SLC4A10/SLC4A8 Antibody (PACO22625)
- SKU:
- PACO22625
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC4A10/SLC4A8 Antibody (PACO22625) |
| Antibody SKU: | PACO22625 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human SLC4A8/10. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, using SLC4A8/10 antibody. |
| Background: | Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity. |
| Synonyms: | electroneutral Na+- driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1; k-NBC3; NBC; NBC3 |
| UniProt Protein Function: | Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH. |
| NCBI Summary: | This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] |
| UniProt Code: | Q6U841 |
| NCBI GenInfo Identifier: | 295821221 |
| NCBI Gene ID: | 57282 |
| NCBI Accession: | NP_001171486.1 |
| UniProt Secondary Accession: | Q6U841,Q4ZFX6, Q8TCP2, Q9HCQ6, B7Z1R0, B7Z2J0, B7ZLC5 B9EG69, F8W675, |
| UniProt Related Accession: | Q6U841 |
| Molecular Weight: | Calculated: 46kDa; 122kDa; 123kDa; 125kDaObserved: 180kDa |
| NCBI Full Name: | sodium-driven chloride bicarbonate exchanger isoform 1 |
| NCBI Synonym Full Names: | solute carrier family 4 member 10 |
| NCBI Official Symbol: | SLC4A10 |
| NCBI Official Synonym Symbols: | NCBE; NBCn2 |
| NCBI Protein Information: | sodium-driven chloride bicarbonate exchanger |
| UniProt Protein Name: | Sodium-driven chloride bicarbonate exchanger |
| UniProt Synonym Protein Names: | Solute carrier family 4 member 10 |
| Protein Family: | Sodium-driven chloride bicarbonate exchanger |
| UniProt Gene Name: | SLC4A10 |
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