SLC43A2 Antibody (PACO20513)
- SKU:
- PACO20513
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC43A2 Antibody (PACO20513) |
| Antibody SKU: | PACO20513 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human SLC43A2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane: Human normal stomach tissue,Primary antibody: PACO20513(SLC43A2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20513(SLC43A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | SLC43A2 (solute carrier family 43, member 2), also known as LAT4 or PP7664, is a 569 amino acid, multi-pass membrane protein that belongs to the SLC43A solute transporter family. Expressed in a variety of tissues with highest expression in kidney and placenta, SLC43A2 functions as a sodium- and chloride-independent transport channel protein that facilitates the transport of large neutral amino acid, across membranes. Overexpression of SLC43A2 is associated with head and neck carcinomas, implicating SLC43A2 as a tumor-associated protein. |
| Synonyms: | solute carrier family 43 (amino acid, system L transporter), member 2 |
| UniProt Protein Function: | SLC43A2: Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. Belongs to the SLC43A transporter (TC 2.A.1.44) family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC familyChromosomal Location of Human Ortholog: 17p13.3Cellular Component: plasma membrane; integral to membraneMolecular Function: L-amino acid transmembrane transporter activityBiological Process: amino acid transport; ion transport; transmembrane transport |
| UniProt Protein Details: | |
| NCBI Summary: | System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8N370 |
| NCBI GenInfo Identifier: | 22748751 |
| NCBI Gene ID: | 124935 |
| NCBI Accession: | NP_689559.1 |
| UniProt Secondary Accession: | Q8N370,Q5CD75, Q6IPM1, Q8NBX1, Q8NC21, Q8WZ00, B7Z6X9 C9JNU8, D3DTH9 |
| UniProt Related Accession: | Q8N370 |
| Molecular Weight: | 62747 |
| NCBI Full Name: | large neutral amino acids transporter small subunit 4 isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 43 (amino acid system L transporter), member 2 |
| NCBI Official Symbol: | SLC43A2 |
| NCBI Official Synonym Symbols: | LAT4 |
| NCBI Protein Information: | large neutral amino acids transporter small subunit 4 |
| UniProt Protein Name: | Large neutral amino acids transporter small subunit 4 |
| UniProt Synonym Protein Names: | L-type amino acid transporter 4; Solute carrier family 43 member 2 |
| Protein Family: | Large neutral amino acids transporter |
| UniProt Gene Name: | SLC43A2 |
| UniProt Entry Name: | LAT4_HUMAN |
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