SLC38A9 Antibody (PACO46882)
- SKU:
- PACO46882
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC38A9 Antibody (PACO46882) |
| Antibody SKU: | PACO46882 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sodium-coupled neutral amino acid, transporter 9 protein (1-119AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Jurkat whole cell lysate. All lanes: SLC38A9 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 64, 53, 57 kDa. Observed band size: 64 kDa.. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO46882 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO46882 at dilution of 1:100. |
| Background: | Lysosomal amino acid, transporter involved in the activation of mTORC1 in response to amino acid,. Probably acts as an amino acid, sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid, sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acid,. Following activation by amino acid, , the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acid, with low capacity and specificity with a slight preference for polar amino acid, , suggesting that it acts as an amino acid, sensor instead. The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor. |
| Synonyms: | Sodium-coupled neutral amino acid, transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11), SLC38A9, URLC11 |
| UniProt Protein Function: | SLC38A9: Putative sodium-dependent amino acid/proton antiporter. Belongs to the amino acid/polyamine transporter 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5q11.2Cellular Component: endoplasmic reticulum; late endosome; lysosomeMolecular Function: amino acid transmembrane transporter activity; protein bindingBiological Process: positive regulation of TOR signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8NBW4 |
| NCBI GenInfo Identifier: | 385137120 |
| NCBI Gene ID: | 153129 |
| NCBI Accession: | NP_001245215.1 |
| UniProt Secondary Accession: | Q8NBW4,Q0P5S0, Q6MZJ8, A0A0A8K8P2, B3KXV1, B7Z7D0 |
| UniProt Related Accession: | Q8NBW4 |
| Molecular Weight: | 56,695 Da |
| NCBI Full Name: | sodium-coupled neutral amino acid transporter 9 isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 38 member 9 |
| NCBI Official Symbol: | SLC38A9 |
| NCBI Official Synonym Symbols: | URLC11 |
| NCBI Protein Information: | sodium-coupled neutral amino acid transporter 9 |
| UniProt Protein Name: | Sodium-coupled neutral amino acid transporter 9 |
| UniProt Synonym Protein Names: | Solute carrier family 38 member 9 |
| Protein Family: | Sodium-coupled neutral amino acid transporter |
| UniProt Gene Name: | SLC38A9 |
| UniProt Entry Name: | S38A9_HUMAN |
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