SLC35C1 Antibody (PACO38686)
- SKU:
- PACO38686
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC35C1 Antibody (PACO38686) |
| Antibody SKU: | PACO38686 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GDP-fucose transporter 1 protein (287-364AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO38686 diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. |
| Synonyms: | GDP-fucose transporter 1 (Solute carrier family 35 member C1), SLC35C1, FUCT1 |
| UniProt Protein Function: | SLC35C1: Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Defects in SLC35C1 are the cause of congenital disorder of glycosylation type 2C (CDG2C); also known as leukocyte adhesion deficiency type II (LAD2). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The clinical features of CDG2C include mental retardation, short stature, facial stigmata, and recurrent bacterial peripheral infections with persistently elevated peripheral leukocytes. Biochemically, CDG2C is characterized by a lack of fucosylated glycoconjugates, including selectin ligands. Belongs to the TPT transporter family. SLC35C subfamily.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11p11.2Cellular Component: Golgi membrane; Golgi apparatus; integral to membraneBiological Process: carbohydrate transport; lipid glycosylation; negative regulation of Notch signaling pathway; transmembrane transportDisease: Congenital Disorder Of Glycosylation, Type Iic |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q96A29 |
| NCBI GenInfo Identifier: | 823671354 |
| NCBI Gene ID: | 55343 |
| NCBI Accession: | AKI70888.1 |
| UniProt Secondary Accession: | Q96A29,Q9BV76, Q9NUJ8, B2RDB2 |
| UniProt Related Accession: | Q96A29 |
| Molecular Weight: | 40 kDa (MW of target protein) |
| NCBI Full Name: | SLC35C1, partial |
| NCBI Synonym Full Names: | solute carrier family 35 (GDP-fucose transporter), member C1 |
| NCBI Official Symbol: | SLC35C1 |
| NCBI Official Synonym Symbols: | CDG2C; FUCT1 |
| NCBI Protein Information: | GDP-fucose transporter 1 |
| UniProt Protein Name: | GDP-fucose transporter 1 |
| UniProt Synonym Protein Names: | Solute carrier family 35 member C1 |
| Protein Family: | |
| UniProt Gene Name: | SLC35C1 |
| UniProt Entry Name: | FUCT1_HUMAN |
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