Name: SLC33A1 Antibody (PACO49122)
SKU: PACO49122
Availability: OutOfStock

Antibody Name:	SLC33A1 Antibody (PACO49122)
Antibody SKU:	PACO49122
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human Acetyl-coenzyme A transporter 1 protein (1-74AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO49122 at dilution of 1:100.
	Western Blot. Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue. All lanes: SLC33A1 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 61 kDa. Observed band size: 50 kDa.
	Immunohistochemistry of paraffin-embedded human kidney tissue using PACO49122 at dilution of 1:100.

Background:	Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
Synonyms:	Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1), SLC33A1, ACATN AT1

UniProt Protein Function:	SLC33A1: Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in SLC33A1 are the cause of congenital cataracts, hearing loss, and neurodegeneration (CCHLND). CCHLND is an autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. Belongs to the SLC33A transporter family.
UniProt Protein Details:	Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 3q25.31 Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; integral to plasma membrane Molecular Function:acetyl-CoA transporter activity; solute:hydrogen symporter activity Biological Process: proton transport; acetyl-CoA transport; transport; transmembrane transport Disease: Spastic Paraplegia 42, Autosomal Dominant; Congenital Cataracts, Hearing Loss, And Neurodegeneration
NCBI Summary:	The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:	O00400
NCBI GenInfo Identifier:	74735319
NCBI Gene ID:	9197
NCBI Accession:	O00400.1
UniProt Secondary Accession:	O00400,B2R5Q2, D3DNK4,
UniProt Related Accession:	O00400
Molecular Weight:	549
NCBI Full Name:	Acetyl-coenzyme A transporter 1
NCBI Synonym Full Names:	solute carrier family 33 (acetyl-CoA transporter), member 1
NCBI Official Symbol:	SLC33A1
NCBI Official Synonym Symbols:	AT1; AT-1; ACATN; SPG42; CCHLND
NCBI Protein Information:	acetyl-coenzyme A transporter 1
UniProt Protein Name:	Acetyl-coenzyme A transporter 1
UniProt Synonym Protein Names:	Solute carrier family 33 member 1
Protein Family:	Acetyl-coenzyme A transporter
UniProt Gene Name:	SLC33A1
UniProt Entry Name:	ACATN_HUMAN