SLC28A1 Antibody (PACO29940)
- SKU:
- PACO29940
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC28A1 Antibody (PACO29940) |
| Antibody SKU: | PACO29940 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sodium/nucleoside cotransporter 1 protein (1-80AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO29940 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO29940 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO29940 at dilution of 1:100. |
| Background: | Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. |
| Synonyms: | Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1), SLC28A1, CNT1 |
| UniProt Protein Function: | SLC28A1: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q25.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: nucleoside transmembrane transporter activity; nucleoside:sodium symporter activity; pyrimidine- and adenine-specific:sodium symporter activityBiological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleoside transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O00337 |
| NCBI GenInfo Identifier: | 229462744 |
| NCBI Gene ID: | 9154 |
| NCBI Accession: | O00337.2 |
| UniProt Secondary Accession: | O00337,O00335, O00336, Q5U5S6, Q5U648, Q9UEZ9, A0AV42 A8K7I2 |
| UniProt Related Accession: | O00337 |
| Molecular Weight: | 20,180 Da |
| NCBI Full Name: | Sodium/nucleoside cotransporter 1 |
| NCBI Synonym Full Names: | solute carrier family 28 member 1 |
| NCBI Official Symbol: | SLC28A1 |
| NCBI Official Synonym Symbols: | CNT1; HCNT1 |
| NCBI Protein Information: | sodium/nucleoside cotransporter 1 |
| UniProt Protein Name: | Sodium/nucleoside cotransporter 1 |
| UniProt Synonym Protein Names: | Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 |
| Protein Family: | Sodium/nucleoside cotransporter |
| UniProt Gene Name: | SLC28A1 |
| UniProt Entry Name: | S28A1_HUMAN |
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