SLC25A37 Antibody (PACO58516)
- SKU:
- PACO58516
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC25A37 Antibody (PACO58516) |
| Antibody SKU: | PACO58516 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Mitoferrin-1 protein (1-44AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58516 diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). |
| Synonyms: | Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37), SLC25A37, MFRN MSCP |
| UniProt Protein Function: | SLC25A37: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p21.2Molecular Function: structural constituent of ribosomeBiological Process: translation |
| UniProt Protein Details: | |
| NCBI Summary: | SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q9NYZ2 |
| NCBI GenInfo Identifier: | 189047115 |
| NCBI Gene ID: | 51312 |
| NCBI Accession: | Q9NYZ2.2 |
| UniProt Secondary Accession: | Q9NYZ2,Q53FT7, Q69YJ8, Q969S1, Q9P0J2, A2RU93 |
| UniProt Related Accession: | Q9NYZ2 |
| Molecular Weight: | 21,125 Da |
| NCBI Full Name: | Mitoferrin-1 |
| NCBI Synonym Full Names: | solute carrier family 25 member 37 |
| NCBI Official Symbol: | SLC25A37 |
| NCBI Official Synonym Symbols: | MSC; MFRN; MSCP; HT015; MFRN1; PRO1278; PRO1584; PRO2217 |
| NCBI Protein Information: | mitoferrin-1 |
| UniProt Protein Name: | Mitoferrin-1 |
| UniProt Synonym Protein Names: | Mitochondrial iron transporter 1; Mitochondrial solute carrier protein; Solute carrier family 25 member 37 |
| Protein Family: | Mitoferrin |
| UniProt Gene Name: | SLC25A37 |
| UniProt Entry Name: | MFRN1_HUMAN |
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