SLC22A6 Antibody (PACO05749)
- SKU:
- PACO05749
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC22A6 Antibody (PACO05749) |
| Antibody SKU: | PACO05749 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human OAT1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | Solute carrier family 22 member 6; Organic anion transporter 1; Hoat1; Renal organic anion transporter 1; hROAT1; PAH transporter; hPAHT; SLC22A6; OAT1; PAHT |
| UniProt Protein Function: | SLC22A6: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integralChromosomal Location of Human Ortholog: 11q12.3Cellular Component: protein complex; integral to plasma membrane; basolateral plasma membrane; plasma membrane; caveolaMolecular Function: protein binding; protein homodimerization activity; inorganic anion exchanger activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; chloride ion bindingBiological Process: sodium-independent organic anion transport; alpha-ketoglutarate transport; response to methotrexate; transmembrane transport; protein homooligomerization; organic anion transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95742 |
| NCBI GenInfo Identifier: | 20070188 |
| NCBI Gene ID: | 9356 |
| NCBI Accession: | NP_004781.2 |
| UniProt Secondary Accession: | O95742 |
| UniProt Related Accession: | O95742,Q4U2R8 |
| Molecular Weight: | 55 |
| NCBI Full Name: | solute carrier family 22 member 6 isoform a |
| NCBI Synonym Full Names: | solute carrier family 22 member 6 |
| NCBI Official Symbol: | SLC22A6 |
| NCBI Official Synonym Symbols: | OAT1; PAHT; HOAT1; ROAT1 |
| NCBI Protein Information: | solute carrier family 22 member 6 |
| UniProt Protein Name: | Solute carrier family 22 member 6 |
| UniProt Synonym Protein Names: | Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 |
| Protein Family: | |
| UniProt Gene Name: | SLC22A6 |
| UniProt Entry Name: | S22A6_HUMAN |
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